An MRI scan revealed damage to his right anterior cruciate ligament sustained during the 5-4 loss at Swansea City on Saturday.
“He will now undergo surgery and his return to action will be confirmed once rehabilitation starts following surgery,” Palace said in a statement on their website without saying how long he would be out for.
Wickham scored in the two games before the defeat by Swansea, a result that left Palace one place above the relegation zone after six consecutive defeats.
Palace host Southampton on Saturday.
(Reporting by Martyn Herman, editing by Ed Osmond)
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